Description
Background
Mouse anti Bovine CD25 antibody, clone IL-A111, recognizes the bovine CD25 cell surface antigen, a ~55 kDa tranamembrane receptor glycoprotein also known as IL-2 receptor alpha chain (IL-2Rα) expressed on activated T and B cells and NK cells. CD25 binds to IL-2, inducing proliferation of the activated cells and can also mediate apoptosis. Bovine CD25 is expressed by activated T cells. This antibody is reported to block the IL-2 driven proliferation of Con A-induced blast cells/bovine lymphocytes.
Specifications
Species Reactivity: Bovine
Source: ILRI clone A111
Specificity: Bovine CD25
Isotype: IgG1
Application
Flow Cytometry: Indirect staining of bovine peripheral blood mononuclear cells to visualise CD25 antigen.
Datasheet
Data
Antibody References
“Naessens, J. et al. 1992. Selection of BoCD25 monoclonal antibodies by screening mouse L cells transfected with the bovine p55-interleukin-2 (IL-2) receptor gene. Immunology. 76 (2): 305-9. Howard, C.J. & Naessens, J. 1993. Summary of workshop findings for cattle (tables 1 and 2). Vet Immunol Immunopathol. 39 (1-3): 25-47. Howard, C.J. et al. 1997. Identification of two distinct populations of dendritic cells in afferent lymph that vary in their ability to stimulate T cells. J Immunol. 159 (11): 5372-82.”
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