Description
Background
Mouse anti Bovine CD172a (SIRPa) antibody, clone IL-A24, recognizes CD172a also known as SIRP alpha or MyD-1 antigen. CD172a is a transmembrane protein involved in cell signal regulation and the IgV domain of CD172a is the receptor for CD47. The interaction of CD47 and SIRPĪ± results in inhibition of phagocytosis by macrophages through tyrosine phosphatase activation and inhibition of myosin accumulation. Bovine CD172a is mainly expressed on macrophages, monocytes, dendritic cells, granulocytes, myeloid progenitors, hematopoietic stem cells, and neurons.
This product is currently out of stock. Expected availability: 4th Quarter 2024
Specifications
Species Reactivity: Bovine
Source: ILRI clone A24
Specificity: Bovine CD172a
Isotype: IgG1
Application
Flow Cytometry: Indirect staining of bovine granulocytes, monocytes and mononuclear phagocyte to visualise CD172a antigen.
Datasheet
Data
Antibody References
Ellis J.A. et al. 1988. Differentiation antigens on bovine mononuclear phagocytes identified by monoclonal antibodies. Vet Immunol Immunopathol.19:325ā40.
Payment
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